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IONS Insider Trading & Form 4 Activity

IONIS PHARMACEUTICALS INC
Last filing: Oct 19, 2026·5 days ago
NEUTRAL · LAST 90 DAYS
50%
buyers
$1.1M
2 buys
$61K
2 sells
$997K
net buying
3
insiders
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Net flow — last 12 months

Monthly net of insider buys minus sells. Green months indicate net buying; red months indicate net selling.

Most active insiders

Ranked by total transaction value over the last 90 days.

INSIDERBOUGHTSOLDNET
Hayden Michael R
Insider
$1.1M
—
$1.1M
Devers Shannon L.
EVP, Chief Human Resources Ofc
—
$59K
-$59K
Swayze Eric
EVP Research
—
$2K
-$2K
O'Neil Patrick R.
EVP CLO & General Counsel
—
—
$0
Birchler Brian
EVP, Corp and Development Ops
—
—
$0
Bennett C Frank
EVP, Chief Scientific Officer
—
—
$0
Monia Brett P
Chief Executive Officer
—
—
$0

Recent transactions

Every Form 4 transaction for IONS, newest first.

SELL
Swayze Eric · EVP Research
Tx Oct 16·Filed Oct 19·EDGAR ↗
53 sh @ $43.54
$2K
SELL
Devers Shannon L. · EVP, Chief Human Resources Ofc
Tx Oct 16·Filed Oct 19·EDGAR ↗
1,357 sh @ $43.54
$59K
EXERCISE
Devers Shannon L. · EVP, Chief Human Resources Ofc
Tx Oct 15·Filed Oct 19·EDGAR ↗
2,820 sh
—
EXERCISE
Swayze Eric · EVP Research
Tx Oct 15·Filed Oct 19·EDGAR ↗
125 sh
—
OTHER
O'Neil Patrick R. · EVP CLO & General Counsel
Tx Aug 31·Filed Sep 2·EDGAR ↗
63 sh @ $51.31
$3K
OTHER
Birchler Brian · EVP, Corp and Development Ops
Tx Aug 31·Filed Sep 2·EDGAR ↗
58 sh @ $51.31
$3K
OTHER
Bennett C Frank · EVP, Chief Scientific Officer
Tx Aug 31·Filed Sep 2·EDGAR ↗
110 sh @ $51.31
$6K
OTHER
Monia Brett P · Chief Executive Officer
Tx Aug 31·Filed Sep 2·EDGAR ↗
98 sh @ $51.31
$5K
BUY
Hayden Michael R · Insider
Tx Jul 31·Filed Jul 31·EDGAR ↗
5,000 sh @ $51.60
$258K
BUY
Hayden Michael R · Insider
Tx Jul 30·Filed Jul 31·EDGAR ↗
15,000 sh @ $53.38
$801K
EXERCISE
Herman Joan E · Insider
Tx Jul 15·Filed Jul 17·EDGAR ↗
5,220 sh
—
EXERCISE
Berthelsen Spencer R · Insider
Tx Jul 15·Filed Jul 17·EDGAR ↗
5,220 sh
—
EXERCISE10b5-1
Diaz Allene M. · Insider
Tx Jul 7·Filed Jul 9·EDGAR ↗
10,111 sh @ $47.11
$476K
SELL10b5-1
Diaz Allene M. · Insider
Tx Jul 7·Filed Jul 9·EDGAR ↗
10,111 sh @ $85.42
$864K
SELL10b5-1
Kordasiewicz Holly B. · EVP, Chief Development Officer
Tx Jul 7·Filed Jul 9·EDGAR ↗
362 sh @ $84.30
$31K
SELL10b5-1
Bennett C Frank · EVP, Chief Scientific Officer
Tx Jul 7·Filed Jul 9·EDGAR ↗
15,000 sh @ $85.46
$1.3M
OTHER10b5-1
Bennett C Frank · EVP, Chief Scientific Officer
Tx Jul 7·Filed Jul 9·EDGAR ↗
15,000 sh
—
SELL10b5-1
Bennett C Frank · EVP, Chief Scientific Officer
Tx Jul 7·Filed Jul 9·EDGAR ↗
5,536 sh @ $83.58
$463K
EXERCISE10b5-1
Klein Joseph III · Insider
Tx Jul 1·Filed Jul 6·EDGAR ↗
11,518 sh @ $39.94
$460K
SELL10b5-1
Klein Joseph III · Insider
Tx Jul 1·Filed Jul 6·EDGAR ↗
99 sh @ $79.45
$8K
SELL10b5-1
Klein Joseph III · Insider
Tx Jul 1·Filed Jul 6·EDGAR ↗
11,419 sh @ $79.04
$903K
SELL10b5-1
O'Neil Patrick R. · EVP CLO & General Counsel
Tx Jun 26·Filed Jun 30·EDGAR ↗
3,069 sh @ $80.00
$246K
SELL10b5-1
Baroldi Joseph · EVP, Chief Business Officer
Tx Jun 26·Filed Jun 30·EDGAR ↗
5,635 sh @ $80.16
$452K
EXERCISE10b5-1
Baroldi Joseph · EVP, Chief Business Officer
Tx Jun 26·Filed Jun 30·EDGAR ↗
3,866 sh @ $56.78
$220K
SELL10b5-1
Schneider Eugene · EVP, Chf Clinical Develop Ofcr
Tx Jun 26·Filed Jun 30·EDGAR ↗
26,000 sh @ $81.05
$2.1M
EXERCISE10b5-1
Schneider Eugene · EVP, Chf Clinical Develop Ofcr
Tx Jun 26·Filed Jun 30·EDGAR ↗
26,000 sh @ $60.89
$1.6M
EXERCISE10b5-1
Baroldi Joseph · EVP, Chief Business Officer
Tx Jun 26·Filed Jun 30·EDGAR ↗
1,769 sh @ $32.60
$58K
SELL10b5-1
Monia Brett P · Chief Executive Officer
Tx Jun 26·Filed Jun 26·EDGAR ↗
50,000 sh @ $80.59
$4.0M
EXERCISE10b5-1
Monia Brett P · Chief Executive Officer
Tx Jun 26·Filed Jun 26·EDGAR ↗
50,000 sh @ $56.78
$2.8M
EXERCISE10b5-1
Monia Brett P · Chief Executive Officer
Tx Jun 25·Filed Jun 26·EDGAR ↗
21,072 sh @ $32.60
$687K
SELL10b5-1
Monia Brett P · Chief Executive Officer
Tx Jun 25·Filed Jun 26·EDGAR ↗
21,072 sh @ $78.49
$1.7M
SELL10b5-1
Swayze Eric · EVP Research
Tx Jun 25·Filed Jun 26·EDGAR ↗
10,602 sh @ $79.18
$839K
EXERCISE10b5-1
Monia Brett P · Chief Executive Officer
Tx Jun 24·Filed Jun 26·EDGAR ↗
14,565 sh @ $32.60
$475K
SELL10b5-1
Monia Brett P · Chief Executive Officer
Tx Jun 24·Filed Jun 26·EDGAR ↗
14,565 sh @ $78.41
$1.1M
EXERCISE10b5-1
Berthelsen Spencer R · Insider
Tx Jun 15·Filed Jun 16·EDGAR ↗
8,000 sh @ $24.42
$195K
SELL10b5-1
Berthelsen Spencer R · Insider
Tx Jun 15·Filed Jun 16·EDGAR ↗
8,000 sh @ $73.49
$588K
SELL10b5-1
Kordasiewicz Holly B. · EVP, Chief Development Officer
Tx Jun 12·Filed Jun 16·EDGAR ↗
41,004 sh @ $73.09
$3.0M
EXERCISE10b5-1
Kordasiewicz Holly B. · EVP, Chief Development Officer
Tx Jun 12·Filed Jun 16·EDGAR ↗
19,895 sh @ $56.78
$1.1M
EXERCISE10b5-1
Kordasiewicz Holly B. · EVP, Chief Development Officer
Tx Jun 12·Filed Jun 16·EDGAR ↗
12,000 sh @ $32.60
$391K
EXERCISE10b5-1
Kordasiewicz Holly B. · EVP, Chief Development Officer
Tx Jun 12·Filed Jun 16·EDGAR ↗
21,000 sh @ $60.89
$1.3M
EXERCISE10b5-1
Kordasiewicz Holly B. · EVP, Chief Development Officer
Tx Jun 12·Filed Jun 16·EDGAR ↗
7,951 sh @ $60.89
$484K
SELL10b5-1
Kordasiewicz Holly B. · EVP, Chief Development Officer
Tx Jun 12·Filed Jun 16·EDGAR ↗
19,842 sh @ $74.05
$1.5M
SELL10b5-1
Berthelsen Spencer R · Insider
Tx Jun 1·Filed Jun 3·EDGAR ↗
8,000 sh @ $75.67
$605K
EXERCISE10b5-1
Berthelsen Spencer R · Insider
Tx Jun 1·Filed Jun 3·EDGAR ↗
8,000 sh @ $24.42
$195K
EXERCISE10b5-1
Monia Brett P · Chief Executive Officer
Tx May 14·Filed May 15·EDGAR ↗
3,220 sh @ $32.60
$105K
SELL10b5-1
Monia Brett P · Chief Executive Officer
Tx May 14·Filed May 15·EDGAR ↗
3,220 sh @ $78.68
$253K
EXERCISE10b5-1
Monia Brett P · Chief Executive Officer
Tx May 13·Filed May 15·EDGAR ↗
1,316 sh @ $32.60
$43K
SELL10b5-1
Monia Brett P · Chief Executive Officer
Tx May 13·Filed May 15·EDGAR ↗
1,316 sh @ $78.01
$103K
SELL10b5-1
Loscalzo Joseph · Insider
Tx May 4·Filed May 6·EDGAR ↗
17,781 sh @ $75.58
$1.3M
SELL10b5-1
Loscalzo Joseph · Insider
Tx May 4·Filed May 6·EDGAR ↗
59,508 sh @ $74.90
$4.5M

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About IONS insider trading data

Form 4 is the SEC filing required when an officer, director, or 10% owner of a public company buys or sells the company's stock. By law, these filings must be submitted within two business days of the trade. Tracenotes pulls every Form 4 filing for IONS from EDGAR, parses it, and surfaces the activity on this page.

What insider buying tells you. Open-market purchases by insiders are widely studied as a meaningful signal. Unlike stock awards (which are compensation, not conviction), an executive spending their own money to buy shares of the company they run is a vote of confidence. Studies have found insider-buying clusters — three or more insiders buying within a short window — outperform the broader market over the following year.

What insider selling tells you. Selling is noisier. Many sales are pre-scheduled under SEC Rule 10b5-1 plans, which let insiders sell on a fixed schedule regardless of company news. We label these "10b5-1" so you can see them. Discretionary sales — sales not tied to a plan — are more meaningful, especially when multiple insiders sell in quick succession.

Tracenotes methodology. We scan EDGAR daily for new Form 4 filings, parse them into individual transactions, and detect clusters when three or more distinct insiders buy or sell within a 14-day window. The data on this page covers the last 12 months. For deeper analysis, Tracenotes also runs language-change detection on 10-K and 10-Q filings — that's our core product.

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Frequently asked questions

What is a Form 4 filing?

Form 4 is the SEC disclosure required when a company insider — an officer, director, or 10% owner — buys or sells the company's stock. By law these filings must be submitted within two business days of the trade.

Is insider buying IONS always bullish?

Open-market purchases by insiders are widely viewed as a bullish signal because executives are spending their own money. Stock awards and option exercises are part of compensation and don't carry the same weight, which is why we treat them separately on this page.

What is a 10b5-1 trade?

A trade made under SEC Rule 10b5-1, which lets insiders pre-schedule sales weeks or months in advance. These sales execute on a fixed plan regardless of company news, so they're a weaker signal than discretionary sales. We label them with a "10b5-1" tag.

What is an insider cluster?

A cluster is when three or more distinct insiders buy or sell within a 14-day window. Clusters are studied as stronger signals than single trades because multiple people independently reach the same view. We surface active clusters on IONIS PHARMACEUTICALS INC (IONS) when they form.

Where does IONS insider trading data come from?

Every Form 4 filing for IONS is sourced directly from SEC EDGAR. Tracenotes scans EDGAR daily, parses each Form 4 into individual transactions, and updates this page within hours of new filings.

Nothing on this page constitutes investment advice. Form 4 data is sourced from SEC EDGAR and provided for research purposes only.

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